2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1397
    RVD-Hpα 1193362-76-3 98%
    RVD-Hpα, an α-hemoglobin-derived peptide containing three additional amino acids, is a CB1 cannabinoid receptor agonist. RVD-Hpα is a positive allosteric modulator of cannabinoid receptor 2.
    RVD-Hpα
  • HY-P1399
    Pep2m, myristoylated 1423381-07-0 98%
    Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).
    Pep2m, myristoylated
  • HY-P1415
    Norleual 334994-34-2 98%
    Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
    Norleual
  • HY-P1424
    Lei-Dab7 1061556-49-7 98%
    Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels.
    Lei-Dab7
  • HY-P1444
    Acein 2022202-76-0 98%
    Acein is a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Acein can promote the release of dopamine. Acein targets angiotensin converting enzyme (ACE I). Angiotensin converting enzyme (ACE I) can be used in nervous system related research.
    Acein
  • HY-P1467
    [Met5]-Enkephalin, amide 60117-17-1 98%
    [Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.
    [Met5]-Enkephalin, amide
  • HY-P1468
    β-Amyloid (1-28) 109770-29-8 98%
    β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
    β-Amyloid (1-28)
  • HY-P1479
    Calmodulin-Dependent Protein Kinase II (290-309) 115044-69-4 98%
    Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
    Calmodulin-Dependent Protein Kinase II (290-309)
  • HY-P1483
    Urotensin II, mouse 405137-01-1 98%
    Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system.
    Urotensin II, mouse
  • HY-P1487
    Pressinoic Acid 35748-51-7 98%
    Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior.
    Pressinoic Acid
  • HY-P1496
    Leucokinin VIII 2703746-05-6 98%
    Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.
    Leucokinin VIII
  • HY-P1498
    Substance P, Free Acid 71977-09-8 98%
    Substance P, Free Acid is a native substance P analog, but shows no biological activity of substance P.
    Substance P, Free Acid
  • HY-P1501
    δ-Sleep Inducing Peptide 62568-57-4 98%
    δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
    δ-Sleep Inducing Peptide
  • HY-P1506
    [Nle11]-Substance P 57462-42-7 98%
    [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
    [Nle11]-Substance P
  • HY-P1510
    β-Amyloid (1-11) 190436-05-6 98%
    β-Amyloid (1-11) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
    β-Amyloid (1-11)
  • HY-P1511
    PACAP-Related Peptide (PRP), human 98%
    PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.
    PACAP-Related Peptide (PRP), human
  • HY-P1521
    β-Amyloid (15-21) 365537-52-6 98%
    β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
    β-Amyloid (15-21)
  • HY-P1524
    β-Amyloid (1-14),mouse,rat 98%
    β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.
    β-Amyloid (1-14),mouse,rat
  • HY-P1543
    Exendin-3 130357-25-4 98.31%
    Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.
    Exendin-3
  • HY-P1544
    Cerebellin 94071-26-8 98%
    Cerebellin is a neuromodulatory peptide widely distributed in the central nervous system.
    Cerebellin
Cat. No. Product Name / Synonyms Application Reactivity